De esta forma, se consigue la estructura primaria de la proteína, es proponer, su secuencia de aminoácidos. Ahora ésta debe plegarse de la forma adecuada para conservarse a su estructura nativa, la que desempeña la función. Anfinsen en sus trabajos con la ribonucleasa A, postuló su hipóexposición que dice que toda la información necesaria
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